Once players have a better understanding of the games mechanics, you are encouraged to add the bonus souls- the Soul of Greed, the Soul of Gluttony, and the Soul of Guppy- to your games. Cooperation, barter and betrayal is encouraged. The first player to end their turn with 4 souls is the winner. In the game, 2-4 players take turns playing loot cards and using items to kill monsters that yield more items, loot, and sometimes souls. Inspired by the hit video game Binding of Isaac, the official card game was launched on Kickstarter in June 2018. The Binding of Isaac: Four Souls is a multiplayer card game about sacrifice, betrayal and hoarding.